Conan O’Brien’s commencement address for the Harvard class of 2000 was one of the best of all time. Somehow, O’Brien managed to top that in his commencement address at the Dartmouth University graduation ceremony last week.

During the speech he indulged in the usual varied brand of humor that made him one of the most prominent talk-show hosts in the country. From sly digs at Dartmouth students (after all he did graduate from rival university, Harvard) to self-deprecating humor, he kept the laughs coming in what was certain to be one of the most entertaining commencement addresses of all time.

However the speech catches you off guard as it becomes unexpectedly moving during the last 7-minues of the speech. O’Brien told graduates “there are few things more liberating in this life than having your worst fear realized” before going on to explain his heartbreak at leaving NBC’s Tonight Show.

The host of TBS’s ‘Conan’ went on to tell graduates “Whether you fear it or not, disappointment will come. The beauty is that through disappointment you can gain clarity, conviction and true originality.”

Watch Conan O’Brien’s commencement address below: